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KMID : 0043320060290121091
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Archives of Pharmacal Research
2006 Volume.29 No. 12 p.1091 ~ p.1095
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Synthesis, Cytotoxicity and Structure-Activity Relationship Study of Terpyridines
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Zhao Long-Xuan
Sherchan Jyoti
Park Jung-Ki
Jahng Yurng-Dong
Jeong Byeong-Seon
Jeong Tae-Cheon
Lee Chong-Soon
Lee Eung-Seok
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Abstract
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For the development of novel antitumor agents, we designed and synthesized terpyridines, and their biological activities were evaluated. Although most of the newly prepared terpyridines showed strong cytotoxicity against several human cancer cell lines, [2,2’;6’,2"]-terpyridine displayed the most significant cytotoxicity.
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KEYWORD
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Terpyridines, Cytotoxicity, Topoisomerase I inhibition, Antitumor agent, Synthesis
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